Charles J Ryan Selected Research

Prednisone (Sone)

1/2022	A Phase Ib/II Study of the CDK4/6 Inhibitor Ribociclib in Combination with Docetaxel plus Prednisone in Metastatic Castration-Resistant Prostate Cancer.
10/2018	Safety and Efficacy of BIND-014, a Docetaxel Nanoparticle Targeting Prostate-Specific Membrane Antigen for Patients With Metastatic Castration-Resistant Prostate Cancer: A Phase 2 Clinical Trial.
1/2018	The IMAAGEN Study: Effect of Abiraterone Acetate and Prednisone on Prostate Specific Antigen and Radiographic Disease Progression in Patients with Nonmetastatic Castration Resistant Prostate Cancer.
12/2017	High-Dose Abiraterone Acetate in Men With Castration Resistant Prostate Cancer.
7/2017	Prognostic Index Model for Progression-Free Survival in Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer Treated With Abiraterone Acetate Plus Prednisone.
7/2017	Safety and Antitumor Activity of Apalutamide (ARN-509) in Metastatic Castration-Resistant Prostate Cancer with and without Prior Abiraterone Acetate and Prednisone.
5/2017	Abiraterone acetate and prednisone in chemotherapy-naïve prostate cancer patients: rationale, evidence and clinical utility.
1/2017	Modeling the Relationship Between Exposure to Abiraterone and Prostate-Specific Antigen Dynamics in Patients with Metastatic Castration-Resistant Prostate Cancer.
1/2017	A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer.
1/2017	Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data.

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Charles J Ryan Research Topics

Disease

148	Prostatic Neoplasms (Prostate Cancer) 02/2022 - 12/2003
42	Neoplasms (Cancer) 12/2021 - 05/2004
23	Neoplasm Metastasis (Metastasis) 01/2021 - 11/2005
21	Disease Progression 01/2021 - 11/2005
7	Circulating Neoplastic Cells 11/2018 - 03/2010
6	Pain (Aches) 08/2021 - 08/2013
4	Hypertension (High Blood Pressure) 01/2018 - 03/2010
3	Neutropenia 01/2022 - 06/2009
2	Cognitive Dysfunction 01/2022 - 01/2018
2	Febrile Neutropenia 01/2022 - 01/2019
2	Fatigue 01/2018 - 12/2007
2	Heart Diseases (Heart Disease) 11/2015 - 02/2015
2	Cancer Pain 10/2015 - 01/2013
2	Renal Cell Carcinoma (Grawitz Tumor) 02/2015 - 09/2011
2	Hypokalemia 05/2011 - 03/2010
2	Leukemia 04/2007 - 05/2006
1	Neurobehavioral Manifestations 01/2022
1	Bites and Stings (Sting) 12/2021
1	Atherosclerosis 04/2021
1	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 01/2021
1	Ovarian Neoplasms (Ovarian Cancer) 09/2020
1	COVID-19 01/2020

Drug/Important Bio-Agent (IBA)

52	AndrogensIBA 10/2021 - 12/2003
31	Abiraterone AcetateIBA 01/2018 - 03/2010
30	Prednisone (Sone)FDA LinkGeneric 01/2022 - 03/2007
25	Hormones (Hormone)IBA 01/2022 - 05/2005
24	Prostate-Specific Antigen (Semenogelase)IBA 01/2022 - 05/2004
23	Docetaxel (Taxotere)FDA Link 01/2022 - 05/2005
22	Androgen Receptors (Androgen Receptor)IBA 02/2022 - 04/2007
15	abirateroneIBA 01/2022 - 05/2011
13	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2013
12	Testosterone (Sustanon)FDA Link 02/2019 - 09/2007
7	AntigensIBA 01/2022 - 01/2009
7	Biological ProductsIBA 01/2021 - 10/2006
6	enzalutamideIBA 01/2020 - 02/2015
5	Poly(ADP-ribose) Polymerase InhibitorsIBA 12/2021 - 01/2016
5	Ketoconazole (Nizoral)FDA LinkGeneric 04/2018 - 04/2007
5	Pharmaceutical PreparationsIBA 01/2018 - 10/2006
5	Mitoxantrone (Novantrone)FDA LinkGeneric 01/2017 - 11/2005
5	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 11/2016 - 12/2007
5	Insulin-Like PeptidesIBA 07/2013 - 03/2007
3	rucaparibIBA 12/2021 - 01/2020
3	Dihydrotestosterone (Androstanolone)IBA 04/2018 - 08/2008
3	Opiate AlkaloidsIBA 01/2018 - 01/2013
3	gallium 68 PSMA-11IBA 01/2018 - 01/2017
3	Insulin (Novolin)FDA Link 01/2018 - 03/2007
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2016 - 05/2015
3	SteroidsIBA 05/2015 - 05/2014
3	Tyrosine Kinase InhibitorsIBA 02/2015 - 09/2009
3	IGF Type 1 Receptor (IGF 1 Receptor)IBA 07/2012 - 03/2007
2	LigandsIBA 01/2022 - 03/2010
2	Steroid Synthesis InhibitorsIBA 01/2020 - 12/2014
2	Radium-223IBA 01/2019 - 10/2014
2	Cell-Free Nucleic AcidsIBA 11/2018 - 01/2017
2	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2018 - 05/2009
2	Dehydroepiandrosterone (DHEA)IBA 12/2017 - 10/2009
2	apalutamideIBA 07/2017 - 12/2016
2	Angiogenesis InhibitorsIBA 04/2017 - 05/2006
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2017 - 03/2006
2	pazopanib FDA Link 04/2017 - 02/2015
2	Phosphotransferases (Kinase)IBA 01/2017 - 08/2008
2	IpilimumabIBA 09/2015 - 01/2009
2	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 06/2015 - 07/2012
2	Masoprocol (Actinex)FDA Link 01/2012 - 08/2008
2	CilengitideIBA 12/2011 - 03/2006
2	IntegrinsIBA 12/2011 - 03/2006
2	pegfilgrastim (Neulasta)FDA Link 06/2011 - 06/2009
2	ixabepilone (BMS 247550)FDA Link 06/2011 - 06/2009
2	MineralocorticoidsIBA 05/2011 - 03/2010
2	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA 03/2010 - 03/2010
2	Androgen Antagonists (Antiandrogens)IBA 05/2009 - 04/2007
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 02/2008 - 10/2007
2	Estramustine FDA Link 06/2007 - 07/2004
2	Imatinib Mesylate (Gleevec)FDA Link 06/2007 - 10/2006
1	MyokinesIBA 01/2022
1	COVID-19 VaccinesIBA 01/2022
1	Metformin (Glucophage)FDA LinkGeneric 01/2022
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2022
1	ribociclibIBA 01/2022
1	Filgrastim (Neupogen)FDA Link 01/2022
1	Chimeric Antigen ReceptorsIBA 12/2021
1	Analgesics (Analgesic Drugs)IBA 08/2021
1	Circulating Tumor DNAIBA 01/2021
1	Interleukin-15 (Interleukin 15)IBA 09/2020
1	Proteins (Proteins, Gene)FDA Link 09/2020
1	cyclohexane- 1,2,4- tris(methylenesulfonate) (CTMS)IBA 12/2019
1	Itraconazole (Sporanox)FDA LinkGeneric 02/2019
1	RadiumIBA 01/2019
1	Carboplatin (JM8)FDA LinkGeneric 11/2018
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 11/2018
1	IsoenzymesIBA 04/2018

Therapy/Procedure

94	Castration 01/2022 - 10/2007
69	Therapeutics 01/2022 - 12/2003
32	Drug Therapy (Chemotherapy) 01/2019 - 11/2002
7	Aftercare (After-Treatment) 10/2018 - 06/2015
6	Radiotherapy 01/2022 - 05/2004
4	Immunotherapy 01/2018 - 12/2007
2	Prostatectomy (Retropubic Prostatectomy) 11/2016 - 10/2006
2	Life Support Care 10/2015 - 11/2014
1	Precision Medicine 08/2021